Research indicates that there are most likely three main physiological changes that occur with consistant use of the Zona Plus:
1. Shown to help the body's autonomic nervous system relax

The
autonomic nervous system (ANS) instinctively manages many of your body's essential functions, such as pupil dilation in your eyes, digestion, your heartbeat and saliva secretion. The ANS is made up of two main parts, the
sympathetic nervous system (SNS) and the
parasympathetic nervous system (PNS). The PNS promotes calming of the nerves and rest, whereas the SNS promotes "fight or flight" responses, such as an increased heart rate. An overactive SNS has been shown to be a fundamental factor in the development of high blood pressure for many individuals.
Research shows that using the Zona Plus helps to put your autonomic nervous system back into balance by calming the SNS and increasing activity in the PNS. This change, called a switch in vagal tone, has been tied to helping insure blood vessels dilate properly, that the body maintains an appropriate heart rate and healthy hormone secretion from the kidneys.
2. Shown to improve artery health

High blood pressure is often characterized by blood vessels that don't expand as much as they should (vasoconstriction), which makes the heart have to work harder to get adequate blood flow and puts excess stress on the arteries and veins. This often occurs because the cells that line the blood vessel, artery, and vein walls (called
endothelium) have become damaged and dysfunctional.
Endothelial dysfunction is often a major culprit in the development of hypertension.
Studies indicate that use of the Zona Plus can result in the reversal of endothelial dysfunction. Endothelial improvement is associated with lower occurrences of cardiovascular disease, heart failure, Peripheral Artery Disease, diabetes, hypertension and other cardiovascular risks.
3. May encourage the body to produce more Nitric Oxide

Researchers hypothesize that the Zona Plus lowers blood pressure partially by an increase in the production of
nitric oxide (NO). Isometric exercise where you are using less than your full strength for short intervals, such as when you use the Zona Plus, has been known to stimulate the creation of nitric oxide. Nitric oxide is known to cause vasodilatation (opening of blood vessels) and has been associated with maintaining normal blood pressure levels.